Protein Name:
Neurogenic locus notch homolog protein 2
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UniprotKB/SwissProt ID: Q04721 (Q04721)
Gene Name:
NOTCH2
Organism: Homo sapiens (Human)
Function: Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus (PubMed:21378985, PubMed:21378989). Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation (PubMed:29149593). Positively regulates self-renewal of liver cancer cells (PubMed:25985737)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane. Nucleus. Cytoplasm
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q04721
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
2085 |
VLTSALSPVI C GPNRSFLSLK |
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| 2 |
2328 |
PAGAPQPQST C PPAVAGPLPT |
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