Protein Name:
Eukaryotic translation initiation factor 4 gamma 1
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UniprotKB/SwissProt ID: Q04637 (Q04637)
Gene Name:
EIF4G1
Organism: Homo sapiens (Human)
Function: Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome (PubMed:29987188). Exists in two complexes, either with EIF1 or with EIF4E (mutually exclusive) (PubMed:29987188). Together with EIF1, is required for leaky scanning, in particular for avoiding cap-proximal start codon (PubMed:29987188). Together with EIF4E, antagonizes the scanning promoted by EIF1-EIF4G1 and locates the start codon (through a TISU element) without scanning (PubMed:29987188). As a member of the eIF4F complex, required for endoplasmic reticulum stress-induced ATF4 mRNA translation (PubMed:29062139)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Nucleus. Cytoplasm, Stress granule
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q04637
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
1265 |
HLNDMKEAVQ C VQELASPSLL |
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| 2 |
1516 |
ARAKLLQKYL C DEQKELQALY |
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| 3 |
662 |
LDPTRLQGIN C GPDFTPSFAN |
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| 4 |
819 |
PNFSVAYANM C RCLMALKVPT |
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| 5 |
821 |
FSVAYANMCR C LMALKVPTTE |
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| 6 |
919 |
KMLTEAIMHD C VVKLLKNHDE |
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| 7 |
934 |
LKNHDEESLE C LCRLLTTIGK |
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| 8 |
936 |
NHDEESLECL C RLLTTIGKDL |
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