Protein Name:
Creatine kinase B-type
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UniprotKB/SwissProt ID: Q04447 (Q04447)
Gene Name:
Ckb
Organism: Mus musculus (Mouse)
Function: Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate) (PubMed:33597756). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa (Probable). Acts as a key regulator of adaptive thermogenesis as part of the futile creatine cycle: localizes to the mitochondria of thermogenic fat cells and acts by mediating phosphorylation of creatine to initiate a futile cycle of creatine phosphorylation and dephosphorylation (PubMed:33597756). During the futile creatine cycle, creatine and N-phosphocreatine are in a futile cycle, which dissipates the high energy charge of N-phosphocreatine as heat without performing any mechanical or chemical work (PubMed:33597756)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm, cytosol. Mitochondrion. Cell membrane
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q04447
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
141 |
VRTGRSIRGF C LPPHCSRGER |
CCCCCCCCCC C CCCCCCCCCC |
6.58% |
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| 2 |
254 |
GNMKEVFTRF C TGLTQIETLF |
CCCCCCCCCC C CCCCCCCCCC |
2.38% |
24895380
22588120
19101475
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| 3 |
283 |
WNPHLGYILT C PSNLGTGLRA |
CCCCCCCCCC C CCCCCCCCCC |
2.89% |
24895380
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