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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Centromere protein C

UniprotKB/SwissProt ID: Q03188 (Q03188)

Gene Name: CENPC

Organism: Homo sapiens (Human)

Function: Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus. Chromosome, centromere, kinetochore. Chromosome, centromere

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR028386 CENP-C/Mif2/cnp3
IPR028931 CENP-C_mid
IPR028052 CENP-C_N_dom
IPR025974 Mif2/CENP-C_cupin
IPR014710 RmlC-like_jellyroll
IPR011051 RmlC_Cupin_sf

The S-nitrosylation sites of Q03188

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 612 GIVGHDEISR C SLSEPLESDE