Protein Name:
Squalene synthase
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UniprotKB/SwissProt ID: Q02769 (Q02769)
Gene Name:
Fdft1
Organism: Rattus norvegicus (Rat)
Function: Catalyzes the condensation of 2 farnesyl pyrophosphate (FPP) moieties to form squalene (PubMed:9575210). Proceeds in two distinct steps. In the first half-reaction, two molecules of FPP react to form the stable presqualene diphosphate intermediate (PSQPP), with concomitant release of a proton and a molecule of inorganic diphosphate. In the second half-reaction, PSQPP undergoes heterolysis, isomerization, and reduction with NADPH or NADH to form squalene. It is the first committed enzyme of the sterol biosynthesis pathway (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Endoplasmic reticulum membrane
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q02769
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
147 |
EKYQTVIADI C HRMGCGMAEF |
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| 2 |
152 |
VIADICHRMG C GMAEFLNKDV |
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| 3 |
374 |
SNIRTQSLPN C QLISRSHYSP |
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