Protein Name:
Ubiquitin-like modifier-activating enzyme 1
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UniprotKB/SwissProt ID: Q02053 (Q02053)
Gene Name:
Uba1
Organism: Mus musculus (Mouse)
Function: Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system (PubMed:1511901). Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Mitochondrion. Nucleus
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q02053
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
1039 |
RHVRALVLEL C CNDESGEDVE |
CCCCCCCCCC C CCCCCCCCCC |
1.17% |
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| 2 |
179 |
LEAQLRVGEF C HSRGIKLVVA |
CCCCCCCCCC C CCCCCCCCCC |
2.18% |
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| 3 |
234 |
VTKDNPGVVT C LDEARHGFET |
CCCCCCCCCC C CCCCCCCCCC |
2.81% |
24926564
21278135
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| 4 |
340 |
HIGFQALHQF C ALHNQPPRPR |
CCCCCCCCCC C CCCCCCCCCC |
2.95% |
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| 5 |
588 |
IDARMYMDRR C VYYRKPLLES |
CCCCCCCCCC C CCCCCCCCCC |
2.1% |
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| 6 |
632 |
QDPPEKSIPI C TLKNFPNAIE |
CCCCCCCCCC C CCCCCCCCCC |
2.82% |
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