Protein Name:
RNA-binding protein EWS
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UniprotKB/SwissProt ID: Q01844 (Q01844)
Gene Name:
EWSR1
Organism: Homo sapiens (Human)
Function: Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3' (PubMed:21256132). Might normally function as a transcriptional repressor (PubMed:10767297). EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus. Cytoplasm. Cell membrane
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q01844
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
384 |
LDDLADFFKQ C GVVKMNKRTG |
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| 2 |
524 |
NVQHRAGDWQ C PNPGCGNQNF |
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| 3 |
529 |
AGDWQCPNPG C GNQNFAWRTE |
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| 4 |
540 |
GNQNFAWRTE C NQCKAPKPEG |
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