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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Hydroxymethylglutaryl-CoA synthase, cytoplasmic

UniprotKB/SwissProt ID: Q01581 (Q01581)

Gene Name: HMGCS1

Organism: Homo sapiens (Human)

Function: Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is converted by HMG-CoA reductase (HMGCR) into mevalonate, a precursor for cholesterol synthesis

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR000590 HMG_CoA_synt_AS
IPR013746 HMG_CoA_synt_C_dom
IPR013528 HMG_CoA_synth_N
IPR010122 HMG_CoA_synthase_euk
IPR016039 Thiolase-like

The S-nitrosylation sites of Q01581

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 12 PGSLPLNAEA C WPKDVGIVAL   
2 224 PIVDGKLSIQ C YLSALDRCYS   
3 232 IQCYLSALDR C YSVYCKKIHA   
4 406 SALDKITASL C DLKSRLDSRT   
5 86 LMERNNLSYD C IGRLEVGTET