Protein Name:
Fatty acid-binding protein 5
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UniprotKB/SwissProt ID: Q01469 (Q01469)
Gene Name:
FABP5
Organism: Homo sapiens (Human)
Function: Intracellular carrier for long-chain fatty acids and related active lipids, such as endocannabinoids, that regulate the metabolism and actions of the ligands they bind. In addition to the cytosolic transport, selectively delivers specific fatty acids from the cytosol to the nucleus, wherein they activate nuclear receptors (PubMed:21395585, PubMed:22170058). Delivers retinoic acid to the nuclear receptor peroxisome proliferator-activated receptor delta; which promotes proliferation and survival. May also serve as a synaptic carrier of endocannabinoid at central synapses and thus controls retrograde endocannabinoid signaling. Modulates inflammation by regulating PTGES induction via NF-kappa-B activation, and prostaglandin E2 (PGE2) biosynthesis during inflammation (By similarity). May be involved in keratinocyte differentiation (PubMed:8092987)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Nucleus. Synapse. Postsynaptic density. Secreted
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q01469
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
120 |
KLKDGKLVVE C VMNNVTCTRI |
CCCCEEEECC E EEECCCCHHH |
2.08% |
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| 2 |
127 |
VVECVMNNVT C TRIYEKVE-- |
CCCCEEEECC E EEECCCCHHH |
1.78% |
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| 3 |
67 |
ESTLKTTQFS C TLGEKFEETT |
CCCCEEEECC E EEECCCCHHH |
3.72% |
2212679
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| 4 |
87 |
TADGRKTQTV C NFTDGALVQH |
CCCCEEEECC E EEECCCCHHH |
3.83% |
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