UniprotKB/SwissProt ID: Q01344 (Q01344)
Gene Name:
IL5RA
Organism: Homo sapiens (Human)
Function: Cell surface receptor that plays an important role in the survival, differentiation, and chemotaxis of eosinophils (PubMed:9378992). Acts by forming a heterodimeric receptor with CSF2RB subunit and subsequently binding to interleukin-5 (PubMed:1495999, PubMed:22528658). In unstimulated conditions, interacts constitutively with JAK2. Heterodimeric receptor activation leads to JAK2 stimulation and subsequent activation of the JAK-STAT pathway (PubMed:9516124)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Membrane
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