Protein Name:
DNA topoisomerase 2-alpha
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UniprotKB/SwissProt ID: Q01320 (Q01320)
Gene Name:
Top2a
Organism: Mus musculus (Mouse)
Function: Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand (PubMed:1331984). May play a role in regulating the period length of BMAL1 transcriptional oscillation (PubMed:24321095)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Nucleus, nucleoplasm. Nucleus. Nucleus, nucleolus
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q01320
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
169 |
GGRNGYGAKL C NIFSTKFTVE |
CCCCCCCCCC H HHCCCCCCCC |
3.46% |
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| 2 |
391 |
TLQAKSFGST C QLSEKFIKAA |
CCCCCCCCCC H HHCCCCCCCC |
4.03% |
20925432
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| 3 |
404 |
SEKFIKAAIG C GIVESILNWV |
CCCCCCCCCC H HHCCCCCCCC |
2.48% |
20925432
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| 4 |
996 |
KVFKLQSSLT C NSMVLFDHVG |
CCCCCCCCCC H HHCCCCCCCC |
4.27% |
20925432
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