Protein Name:
Cystic fibrosis transmembrane conductance regulator
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UniprotKB/SwissProt ID: Q00PJ2 (Q00PJ2)
Gene Name:
CFTR
Organism: Atelerix albiventris (Middle-African hedgehog)
Function: Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). The ion channel is also permeable to HCO(3)(-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. Modulates the activity of the epithelial sodium channel (ENaC) complex, in part by regulating the cell surface expression of the ENaC complex. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the transporter SLC4A7. Can inhibit the chloride channel activity of ANO1 (By similarity). Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Apical cell membrane. Early endosome membrane. Cell membrane. Recycling endosome membrane. Endoplasmic reticulum membrane. Nucleus
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Graphical Visualization of S-nitrosylation Sites:
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