UniprotKB/SwissProt ID: Q00954 (Q00954)
Gene Name:
Scn1b
Organism: Rattus norvegicus (Rat)
Function: Regulatory subunit of multiple voltage-gated sodium (Nav) channels directly mediating the depolarization of excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na+ ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues. The accessory beta subunits participate in localization and functional modulation of the Nav channels (PubMed:1375395, PubMed:15178439, PubMed:28012039, PubMed:8021275, PubMed:8282123). Modulates the activity of SCN1A/Nav1.1, SCN2A/Nav1.2, SCN3A/Nav1.3, SCN4A/Nav1.4, SCN5A/Nav1.5, SCN8A/Nav1.6, SCN9A/Nav1.7 and SCN10A/Nav1.8 (By similarity) (PubMed:1375395, PubMed:15178439, PubMed:28012039, PubMed:8021275, PubMed:8282123)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane. Perikaryon. Cell projection. Cell projection, axon
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