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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Clathrin heavy chain 1
UniprotKB/SwissProt ID: Q00610 (Q00610)

Gene Name: CLTC

Organism: Homo sapiens (Human)

Function: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network. Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge (PubMed:15858577, PubMed:16968737, PubMed:21297582). The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:23532825). Plays a role in early autophagosome formation (PubMed:20639872). Interaction with DNAJC6 mediates the recruitment of HSPA8 to the clathrin lattice and creates local destabilization of the lattice promoting uncoating (By similarity)

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasmic vesicle membrane. Membrane, coated pit. Melanosome. Cytoplasm, cytoskeleton, spindle

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR016024 ARM-type_fold
IPR055358 CHCR
IPR000547 Clathrin_H-chain/VPS_repeat
IPR015348 Clathrin_H-chain_linker_core
IPR016025 Clathrin_H-chain_N
IPR022365 Clathrin_H-chain_propeller_rpt
IPR016341 Clathrin_heavy_chain
IPR011990 TPR-like_helical_dom_sf
The S-nitrosylation sites of Q00610
No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 1102 LDRAYEFAER C NEPAVWSQLA  CCCCCCCCHH H HHHHHCCCCC  5.21% 2212679
2 1260 TRTWKEVCFA C VDGKEFRLAQ  CCCCCCCCHH H HHHHHCCCCC  1.12%
3 151 MFDRHSSLAG C QIINYRTDAK  CCCCCCCCHH H HHHHHCCCCC  1.87% 19483679
4 1528 NNRWKQSVEL C KKDSLYKDAM  CCCCCCCCHH H HHHHHCCCCC  3.05%
5 217 EGNAEESTLF C FAVRGQAGGK  CCCCCCCCHH H HHHHHCCCCC  2.11%
6 292 IHLYDLETGT C IYMNRISGET  CCCCCCCCHH H HHHHHCCCCC  1.91%
7 436 QLNKYESLEL C RPVLQQGRKQ  CCCCCCCCHH H HHHHHCCCCC  3.18%
8 459 EKWLKEDKLE C SEELGDLVKS  CCCCCCCCHH H HHHHHCCCCC  10.07%
9 491 RANVPNKVIQ C FAETGQVQKI  CCCCCCCCHH H HHHHHCCCCC  2.1% 19483679
10 617 HYDRAHIAQL C EKAGLLQRAL  CCCCCCCCHH H HHHHHCCCCC  3.16%
11 736 DVHFKYIQAA C KTGQIKEVER  CCCCCCCCHH H HHHHHCCCCC  4.55% 19483679
12 753 EVERICRESN C YDPERVKNFL  CCCCCCCCHH H HHHHHCCCCC  5.92%
13 778 LTDQLPLIIV C DRFDFVHDLV  CCCCCCCCHH H HHHHHCCCCC  1.88%
14 824 VVIGGLLDVD C SEDVIKNLIL  CCCCCCCCHH H HHHHHCCCCC  4.88%
15 870 PWLEARIHEG C EEPATHNALA  CCCCCCCCHH H HHHHHCCCCC  4.95% 37478858
16 918 YCEKRDPHLA C VAYERGQCDL  CCCCCCCCHH H HHHHHCCCCC  1.96% 19483679
37478858
17 926 LACVAYERGQ C DLELINVCNE  CCCCCCCCHH H HHHHHCCCCC  7.79% 19483679
18 934 GQCDLELINV C NENSLFKSLS  CCCCCCCCHH H HHHHHCCCCC  4.58% 19483679