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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Xanthine dehydrogenase/oxidase
UniprotKB/SwissProt ID: Q00519 (Q00519)

Gene Name: Xdh

Organism: Mus musculus (Mouse)

Function: Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid. Contributes to the generation of reactive oxygen species

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Peroxisome. Secreted

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR002888 2Fe-2S-bd
IPR036884 2Fe-2S-bd_dom_sf
IPR036010 2Fe-2S_ferredoxin-like_sf
IPR001041 2Fe-2S_ferredoxin-type
IPR006058 2Fe2S_fd_BS
IPR000674 Ald_Oxase/Xan_DH_a/b
IPR036856 Ald_Oxase/Xan_DH_a/b_sf
IPR016208 Ald_Oxase/xanthine_DH-like
IPR008274 AldOxase/xan_DH_MoCoBD1
IPR046867 AldOxase/xan_DH_MoCoBD2
IPR037165 AldOxase/xan_DH_Mopterin-bd_sf
IPR012675 Beta-grasp_dom_sf
IPR005107 CO_DH_flav_C
IPR036683 CO_DH_flav_C_dom_sf
IPR016166 FAD-bd_PCMH
IPR036318 FAD-bd_PCMH-like_sf
IPR016167 FAD-bd_PCMH_sub1
IPR016169 FAD-bd_PCMH_sub2
IPR002346 Mopterin_DH_FAD-bd
IPR022407 OxRdtase_Mopterin_BS
IPR014309 Xanthine_DH_Mopterin-bd_su
IPR014307 Xanthine_DH_ssu
The S-nitrosylation sites of Q00519
No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 828 AAYKTGRPVR C MLDRDEDMLI  CCCCCHHEEE E EECCEEEEEC  3.02% 22178444
2 970 QKLEGFTLPR C WDECIASSQY  CCCCCHHEEE E EECCEEEEEC  5.19%
3 974 GFTLPRCWDE C IASSQYQARK  CCCCCHHEEE E EECCEEEEEC  2.67%