Protein Name:
Cyclic nucleotide-gated channel alpha-2
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UniprotKB/SwissProt ID: Q00195 (Q00195)
Gene Name:
Cnga2
Organism: Rattus norvegicus (Rat)
Function: Pore-forming subunit of the olfactory cyclic nucleotide-gated channel. Operates in the cilia of olfactory sensory neurons where chemical stimulation of the odorant is converted to an electrical signal. Mediates odorant-induced cAMP-dependent Ca(2+) influx triggering neuron depolarization. The rise of intracellular Ca(2+) levels potentiates the olfactory response by activating Ca(2+)-dependent Cl(-) channels, but it also serves as a negative feedback signal to desensitize the channel for rapid adaptation to odorants. Conducts cAMP- and cGMP-gated ion currents, with permeability for monovalent and divalent cations
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell projection, cilium membrane
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q00195
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
460 |
TLKKVRIFQD C EAGLLVELVL |
CCCCCCCCCC C CCCCCCCCCC |
2.41% |
22178444
10809749
15688001
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