Protein Name:
Phospholipid-transporting ATPase IB
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UniprotKB/SwissProt ID: P98200 (P98200)
Gene Name:
Atp8a2
Organism: Mus musculus (Mouse)
Function: Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids (PubMed:22912588). Able to translocate phosphatidylserine, but not phosphatidylcholine (By similarity). Phospholipid translocation also seems to be implicated in vesicle formation and in uptake of lipid signaling molecules. Reconstituted to liposomes, the ATP8A2:TMEM30A flippase complex predominantly transports phosphatidylserine (PS) and to a lesser extent phosphatidylethanolamine (PE) (PubMed:22912588). Phospholipid translocation is not associated with a countertransport of an inorganic ion or other charged substrate from the cytoplasmic side toward the exoplasm in connection with the phosphorylation from ATP (By similarity). ATP8A2:TMEM30A may be involved in regulation of neurite outgrowth (PubMed:22641037). Proposed to function in the generation and maintenance of phospholipid asymmetry in photoreceptor disk membranes and neuronal axon membranes. May be involved in vesicle trafficking in neuronal cells. Required for normal visual and auditory function; involved in photoreceptor and inner ear spiral ganglion cell survival (PubMed:24413176)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Membrane. Golgi apparatus membrane. Endosome membrane. Cell membrane. Photoreceptor outer segment membrane. Photoreceptor inner segment membrane
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Graphical Visualization of S-nitrosylation Sites:
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