Protein Name:
Very low-density lipoprotein receptor
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UniprotKB/SwissProt ID: P98156 (P98156)
Gene Name:
Vldlr
Organism: Mus musculus (Mouse)
Function: Multifunctional cell surface receptor that binds VLDL and transports it into cells by endocytosis and therefore plays an important role in energy metabolism (PubMed:11108739, PubMed:24293365). Also binds to a wide range of other molecules including Reelin/RELN or apolipoprotein E/APOE-containing ligands as well as clusterin/CLU. In the off-state of the pathway LRP8 and VLDLR form homo or heterooligomers (By similarity). Upon binding to ligands, homooligomers are rearranged to higher order receptor clusters that transmit the extracellular RELN signal to intracellular signaling processes by binding to DAB1 on its cytoplasmic tail (By similarity). This interaction results in phosphorylation of DAB1 leading to the ultimate cell responses required for the correct positioning of newly generated neurons (PubMed:23506116). Later, mediates a stop signal for migrating neurons, preventing them from entering the marginal zone (PubMed:17913789)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Membrane. Membrane, clathrin-coated pit
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P98156
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
120 |
MRTCRINEIS C GARSTQCIPV |
CCHHHHHHHH H HHHHHCCCCC |
6.41% |
21278135
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