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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Mucin-5AC

UniprotKB/SwissProt ID: P98088 (P98088)

Gene Name: MUC5AC

Organism: Homo sapiens (Human)

Function: Gel-forming glycoprotein of gastric and respiratory tract epithelia that protects the mucosa from infection and chemical damage by binding to inhaled microorganisms and particles that are subsequently removed by the mucociliary system (PubMed:14535999, PubMed:14718370). Interacts with H.pylori in the gastric epithelium, Barrett's esophagus as well as in gastric metaplasia of the duodenum (GMD) (PubMed:14535999)

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Secreted

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR006207 Cys_knot_C
IPR050780 Mucin_vWF_Thrombospondin_sf
IPR036084 Ser_inhib-like_sf
IPR002919 TIL_dom
IPR014853 VWF/SSPO/ZAN-like_Cys-rich_dom
IPR001007 VWF_dom
IPR001846 VWF_type-D
IPR025155 WxxW_domain

The S-nitrosylation sites of P98088

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 1819 VQCSREEGLV C RNQDQQGPFK   
2 2192 VQCSREEGLV C RNQDQQGPFK   
3 291 LVDVGSYLEA C RQDLCFCEDT   
4 3298 VQCSREEGLV C RNQDQQGPFK   
5 3596 VQCSREEGLV C RNQDQQGPFK   
6 4029 VQCSREEGLV C RNQDQQGPFK   
7 4703 VQCSREEGLV C RNQDQQGPFK