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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Dipeptidyl peptidase 1

UniprotKB/SwissProt ID: P97821 (P97821)

Gene Name: Ctsc

Organism: Mus musculus (Mouse)

Function: Thiol protease. Has dipeptidylpeptidase activity. Active against a broad range of dipeptide substrates composed of both polar and hydrophobic amino acids. Proline cannot occupy the P1 position and arginine cannot occupy the P2 position of the substrate. Can act as both an exopeptidase and endopeptidase. Activates serine proteases such as elastase, cathepsin G and granzymes A and B

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Lysosome

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR039412 CatC
IPR014882 CathepsinC_exc
IPR036496 CathepsinC_exc_dom_sf
IPR038765 Papain-like_cys_pep_sf
IPR025661 Pept_asp_AS
IPR000169 Pept_cys_AS
IPR025660 Pept_his_AS
IPR013128 Peptidase_C1A
IPR000668 Peptidase_C1A_C

The S-nitrosylation sites of P97821

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 447 YFRIRRGTDE C AIESIAVAAI  CCCCHHHHHH H HHHHHHCHHC  5.28% 21278135