UniprotKB/SwissProt ID: P97772 (P97772)
Gene Name:
Grm1
Organism: Mus musculus (Mouse)
Function: G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum (By. similarity). May function in the light response in the retina (PubMed:26427409). Induces GRID1 and GRID2 cation-channel activation via GNAQ-PLC-PKC pathway in dopaminergic neurons and cerebellar Purkinje cell, respectively (PubMed:24357660, PubMed:27276689, PubMed:28696429)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane. Postsynaptic cell membrane. Cell projection, dendrite
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