Protein Name:
G protein-coupled receptor kinase 6
|
UniprotKB/SwissProt ID: P97711 (P97711)
Gene Name:
Grk6
Organism: Rattus norvegicus (Rat)
Function: Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (By similarity). Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro) (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Membrane
|
|
|
Graphical Visualization of S-nitrosylation Sites:
|
|
