Protein Name:
Cullin-associated NEDD8-dissociated protein 1
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UniprotKB/SwissProt ID: P97536 (P97536)
Gene Name:
Cand1
Organism: Rattus norvegicus (Rat)
Function: Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange factor. The exchange activity of CAND1 is coupled with cycles of neddylation conjugation: in the deneddylated state, cullin-binding CAND1 binds CUL1-RBX1, increasing dissociation of the SCF complex and promoting exchange of the F-box protein. Probably plays a similar role in other cullin-RING E3 ubiquitin ligase complexes (By similarity). May indirectly enhance transcription from various types of promoters
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Nucleus
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P97536
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
1007 |
PQPIDPLLKN C IGDFLKTLED |
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| 2 |
1134 |
FLMLVRLSTL C PSAVLQRLDR |
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| 3 |
237 |
SMSTTRTYIQ C IAAISRQAGH |
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| 4 |
264 |
EKIIPLVVKF C NVDDDELREY |
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| 5 |
802 |
HKQSYYSIAK C VAALTRACPK |
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| 6 |
954 |
EEGTRNVVAE C LGKLTLIDPE |
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