Protein Name:
Flavin-containing monooxygenase 3
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UniprotKB/SwissProt ID: P97501 (P97501)
Gene Name:
Fmo3
Organism: Mus musculus (Mouse)
Function: Essential hepatic enzyme that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including drugs as well as dietary compounds. Plays an important role in the metabolism of trimethylamine (TMA), via the production of trimethylamine N-oxide (TMAO) metabolite. TMA is generated by the action of gut microbiota using dietary precursors such as choline, choline containing compounds, betaine or L-carnitine. By regulating TMAO concentration, FMO3 directly impacts both platelet responsiveness and rate of thrombus formation
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Microsome membrane. Endoplasmic reticulum membrane
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P97501
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
197 |
VLVIGLGNSG C DIAAELSHVA |
CCCEEEEECC C HHHHHHHHHH |
3.25% |
22178444
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| 2 |
294 |
FNDELPARIL C GMVTIKPNVK |
CCCEEEEECC C HHHHHHHHHH |
2.84% |
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| 3 |
397 |
RWAAQVIKGT C TLPSVNDMMD |
CCCEEEEECC C HHHHHHHHHH |
5.12% |
22178444
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