UniprotKB/SwissProt ID: P93002 (P93002)
Gene Name:
NPR1
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Salicylic acid (SA)-binding substrate-specific adapter of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Transcription cofactor that represses gene expression in the absence of salicylic acid (SA), when attached to negative cis-elements (W-box) with WRKY transcription factors (e.g. WRKY70), but stimulates gene expression upon activation by SA, when sumoylated and attached to positive cis-elements (as-1) with TGA transcription factors (e.g. TGA3), thus confering immunity through a series of gene regulations ending in a significant increase in antimicrobial and defense genes expression (e.g. PR-1 and PR-2) (PubMed:26269953, PubMed:35545668). Binds to SA with low capacity; this leads to conformational changes (PubMed:32788727, PubMed:35545668). Key positive regulator of the SA-dependent signaling pathway that negatively regulates jasmonic acid (JA)-dependent signaling pathway. Controls the onset of systemic acquired resistance (SAR). Upon SAR induction, a biphasic change in cellular reduction potential occurs, resulting in reduction of the cytoplasmic oligomeric form to dimeric and monomeric forms, which accumulate in the nucleus and activate gene expression (PubMed:35545668). Appears to control lesion expansion by acting as an inhibitor of programmed cell death (PCD) during effector-triggered immunity (ETI) that occurs in response to incompatible interaction with avirulent pathogenic bacteria (i.e. Pseudomonas syringae ES4326/avrRpt2) ending in a hypersensitive response (HR) (PubMed:22699612). Phosphorylated form is target of proteasome degradation
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Nucleus. Nucleus, nuclear body
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