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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: SNF1-related protein kinase catalytic subunit alpha KIN11

UniprotKB/SwissProt ID: P92958 (P92958)

Gene Name: KIN11

Organism: Arabidopsis thaliana (Mouse-ear cress)

Function: Catalytic subunit of the probable trimeric SNF1-related protein kinase (SnRK) complex, a central regulator of cellular energy homeostasis, which, in response to seemingly unrelated darkness, sugar and stress conditions, activates energy-producing pathways and inhibits energy-consuming processes. May play a role in a signal transduction cascade regulating gene expression and carbohydrate metabolism in higher plants. The SnRK complex may also be involved in the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase and in assimilation of nitrogen by phosphorylating nitrate reductase (PubMed:17671505). In vitro, KIN11 exhibits kinase activity on sucrose phosphate synthase and the kinase activity is inhibited by PRL1 (PubMed:10220464). May be a subunit of a SCF ubiquitin ligase complex and thus be involved in proteasomal ubiquitination (PubMed:11387208). Involved in innate antiviral defenses (PubMed:12671096). Phosphorylates REM4.1 in vitro (PubMed:25289013). Phosphorylates ADK2 in vitro (PubMed:24498147)

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Plastid, chloroplast. Cytoplasm. Endoplasmic reticulum

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR028375 KA1/Ssp2_C
IPR001772 KA1_dom
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
IPR015940 UBA
IPR009060 UBA-like_sf

The S-nitrosylation sites of P92958

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 178 MRDGHFLKTS C GSPNYAAPEV