UniprotKB/SwissProt ID: P90489 (P90489)
Gene Name:
K5
Organism: Human herpesvirus 8 type P (isolate GK18) (HHV-8)
Function: Membrane-bound E3 ubiquitin ligase expressed at the immediate early stage of viral reactivation to mediate polyubiquitination of various host membrane proteins related to the immune response (PubMed:10799607, PubMed:10859362, PubMed:11413168, PubMed:24899205). Promotes ubiquitination and subsequent degradation of host MHC-I, CD86, DC-SIGN and DC-SIGNR, ICAM1 and CD1D molecules, presumably to prevent lysis of infected cells by cytotoxic T-lymphocytes and NK cell (PubMed:11413168, PubMed:23460925). Plays a role in the down-regulation of the host stress-induced NKG2D ligands MICA, MICB and CLEC2B, which enable immune cells expressing the NKG2D receptor to recognize and annihilate infected cells prior to viral spread (PubMed:18230726). Alters monocyte metabolism and proliferation by mediating rapid internalization of cellular growth factor-binding receptor tyrosine kinases from the surface leading to increased signaling (PubMed:21490960)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Host cell membrane. Host endoplasmic reticulum
|
|
|
