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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Large ribosomal subunit protein uL16-like

UniprotKB/SwissProt ID: P86048 (P86048)

Gene Name: Rpl10l

Organism: Mus musculus (Mouse)

Function: Testis-specific component of the ribosome, which is required for the transition from prophase to metaphase in male meiosis I (PubMed:28502657). Compensates for the inactivated X-linked RPL10 paralog during spermatogenesis (PubMed:28502657). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:28502657). The male germ cell-specific ribosome displays a ribosomal polypeptide exit tunnel of distinct size and charge states compared with the classical ribosome (PubMed:36517592). It is responsible for regulating the biosynthesis and folding of a subset of male germ-cell-specific proteins that are essential for the formation of sperm (PubMed:36517592)

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR047873 Ribosomal_uL16
IPR018255 Ribosomal_uL16_CS_euk_arc
IPR016180 Ribosomal_uL16_dom
IPR001197 Ribosomal_uL16_euk_arch
IPR036920 Ribosomal_uL16_sf

The S-nitrosylation sites of P86048

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 105 HVIRINKMLS C AGADRLQTGM  CCCCCHHHHH H HCCCCCCHHH  3.4% 20925432
2 195 VAAKRLIPDG C GVKYIPERGP  CCCCCHHHHH H HCCCCCCHHH  8.05%
3 23 KNKPYPKSRF C RGVPDAKIRI  CCCCCHHHHH H HCCCCCCHHH  3.44%
4 49 KKAKVDEFPL C GHMVSDEYEQ  CCCCCHHHHH H HCCCCCCHHH  3.42%
5 71 SSEALEAARI C ANKYMVKSCG  CCCCCHHHHH H HCCCCCCHHH  2.59%
6 80 ICANKYMVKS C GKDGFHIRVR  CCCCCHHHHH H HCCCCCCHHH  6.95%