Protein Name:
Serine/arginine-rich splicing factor 3
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UniprotKB/SwissProt ID: P84103 (P84103)
Gene Name:
SRSF3
Organism: Homo sapiens (Human)
Function: Splicing factor, which binds the consensus motif 5'-C[ACU][AU]C[ACU][AC]C-3' within pre-mRNA and promotes specific exons inclusion during alternative splicing (PubMed:17036044, PubMed:26876937, PubMed:32440474). Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites within exons (PubMed:26876937). Also functions as an adapter involved in mRNA nuclear export (PubMed:11336712, PubMed:18364396, PubMed:28984244). Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity (PubMed:11336712, PubMed:18364396). Involved in nuclear export of m6A-containing mRNAs via interaction with YTHDC1: interaction with YTHDC1 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export (PubMed:28984244)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus. Nucleus speckle. Cytoplasm
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P84103
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
10 |
-MHRDSCPLD C KVYVGNLGNN |
CCCCCCCCCC E EEEECCCCCC |
4.18% |
2212679
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| 2 |
6 |
-----MHRDS C PLDCKVYVGN |
CCCCCCCCCC E EEEECCCCCC |
4.55% |
2212679
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| 3 |
72 |
AVRELDGRTL C GCRVRVELSN |
CCCCCCCCCC E EEEECCCCCC |
4.83% |
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