Protein Name:
Rho-related GTP-binding protein RhoG
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UniprotKB/SwissProt ID: P84095 (P84095)
Gene Name:
RHOG
Organism: Homo sapiens (Human)
Function: Plays a role in immunological synaptic F-actin density and architecture organization (PubMed:33513601). Regulates actin reorganization in lymphocytes, possibly through the modulation of Rac1 activity (PubMed:33513601). Required for the formation of membrane ruffles during macropinocytosis (PubMed:15133129). Plays a role in cell migration and is required for the formation of cup-like structures during trans-endothelial migration of leukocytes (PubMed:17875742). Binds phospholipids in an activation-dependent manner; thereby acting as an anchor for other proteins to the plasma membrane (PM) (PubMed:33513601). Plays a role in exocytosis of cytotoxic granules (CG) by lymphocytes/Component of the exocytosis machinery in natural killer (NK) and CD8+ T cells (PubMed:33513601). Promotes the docking of cytotoxic granules (CG) to the plasma membrane through the interaction with UNC13D (PubMed:33513601). Involved in the cytotoxic activity of lymphocytes/primary CD8+ T cells (PubMed:33513601) (Microbial infection) In case of Salmonella enterica infection, activated by SopB and ARHGEF26/SGEF, which induces cytoskeleton rearrangements and promotes bacterial entry
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P84095
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
157 |
KQIHAVRYLE C SALQQDGVKE |
CCCCEEEEEC C CCCCCEEEEE |
2.38% |
21278135
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| 2 |
6 |
-----MQSIK C VVVGDGAVGK |
CCCCEEEEEC C CCCCCEEEEE |
2.4% |
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