Protein Name:
Complexin-2
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UniprotKB/SwissProt ID: P84086 (P84086)
Gene Name:
Cplx2
Organism: Mus musculus (Mouse)
Function: Negatively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles (PubMed:11163241, PubMed:23345244). Also involved in mast cell exocytosis (PubMed:11163241). Although not essential for development, seems critical for the acquisition of higher cognitive functions in the adult brain (PubMed:12915444)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm, cytosol. Presynapse. Nucleus. Perikaryon
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P84086
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
105 |
TRPKKAIPAG C GDEEEEEEES |
CCHHHHHHCC C CCHHHHHHCC |
7.25% |
22178444
24895380
19101475
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| 2 |
90 |
AEEKAALEQP C EGSLTRPKKA |
CCHHHHHHCC C CCHHHHHHCC |
10.39% |
22178444
24895380
19101475
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