Protein Name:
Eukaryotic translation initiation factor 2 subunit 3, X-linked
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UniprotKB/SwissProt ID: P81795 (P81795)
Gene Name:
Eif2s3
Organism: Rattus norvegicus (Rat)
Function: Member of the eIF2 complex that functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form the 43S pre-initiation complex (43S PIC). Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex. In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF-2B (By similarity). Along with its paralog on chromosome Y, may contribute to spermatogenesis up to the round spermatid stage (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm, cytosol
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P81795
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
105 |
SCPRPECYRS C GSSTPDEFPT |
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| 2 |
269 |
IRSFDVNKPG C EVDDLKGGVA |
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| 3 |
434 |
LGKIVLTNPV C TEVGEKIALS |
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