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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: T-complex protein 1 subunit epsilon
UniprotKB/SwissProt ID: P80316 (P80316)

Gene Name: Cct5

Organism: Mus musculus (Mouse)

Function: Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR012718 Chap_CCT_epsi
IPR017998 Chaperone_TCP-1
IPR002194 Chaperonin_TCP-1_CS
IPR002423 Cpn60/GroEL/TCP-1
IPR027409 GroEL-like_apical_dom_sf
IPR027413 GROEL-like_equatorial_sf
IPR027410 TCP-1-like_intermed_sf
IPR053374 TCP-1_chaperonin
IPR054827 thermosome_alpha
The S-nitrosylation sites of P80316
No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 181 TTLGSKVINS C HRQMAEIAVN  CCCCCCEEEC C CCCEEEEEEC  2.37% 20925432
2 253 VVDAKIAILT C PFEPPKPKTK  CCCCCCEEEC C CCCEEEEEEC  3.05% 20925432
21278135
3 407 EAKRSLHDAL C VIRNLIRDNR  CCCCCCEEEC C CCCEEEEEEC  2.28% 24926564
20925432
21278135
4 429 VYGGGAAEIS C ALAVSQEADK  CCCCCCEEEC C CCCEEEEEEC  4.4%
5 493 KESNPALGID C LHKGSNDMQY  CCCCCCEEEC C CCCEEEEEEC  3.97% 20925432