Protein Name:
DENN domain-containing protein 2B
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UniprotKB/SwissProt ID: P78524 (P78524)
Gene Name:
DENND2B
Organism: Homo sapiens (Human)
Function: May be involved in cytoskeletal organization and tumorogenicity. Seems to be involved in a signaling transduction pathway leading to activation of MAPK1/ERK2. Plays a role in EGFR trafficking from recycling endosomes back to the cell membrane (PubMed:29030480) Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form May block ERK2 activation stimulated by ABL1 (Probable). May alter cell morphology and cell growth (Probable)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm, cell cortex. Cell membrane. Recycling endosome
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P78524
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
235 |
LRRMSRTFSE C SYPETEEEGE |
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