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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Phosphatidylinositol 5-phosphate 4-kinase type-2 beta
UniprotKB/SwissProt ID: P78356 (P78356)

Gene Name: PIP4K2B

Organism: Homo sapiens (Human)

Function: Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate (PubMed:26774281, PubMed:9038203). Preferentially utilizes GTP, rather than ATP, for PI(5)P phosphorylation and its activity reflects changes in direct proportion to the physiological GTP concentration (PubMed:26774281). Its GTP-sensing activity is critical for metabolic adaptation (PubMed:26774281). PIP4Ks negatively regulate insulin signaling through a catalytic-independent mechanism. They interact with PIP5Ks and suppress PIP5K-mediated PtdIns(4,5)P2 synthesis and insulin-dependent conversion to PtdIns(3,4,5)P3 (PubMed:31091439)

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Endoplasmic reticulum membrane. Cell membrane. Nucleus. Cytoplasm

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR027483 PInositol-4-P-4/5-kinase_C_sf
IPR002498 PInositol-4-P-4/5-kinase_core
IPR027484 PInositol-4-P-5-kinase_N
IPR023610 PInositol-4/5-P-5/4-kinase
The S-nitrosylation sites of P78356
No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 99 LPSRFKFKEY C PMVFRNLRER    37478858