Protein Name:
General transcription factor II-I
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UniprotKB/SwissProt ID: P78347 (P78347)
Gene Name:
GTF2I
Organism: Homo sapiens (Human)
Function: Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and PHOX1 and interacts cooperatively with PHOX1 to promote serum-inducible transcription of a reporter gene deriven by the C-FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box. Required for the formation of functional ARID3A DNA-binding complexes and for activation of immunoglobulin heavy-chain transcription upon B-lymphocyte activation
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Nucleus
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P78347
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
121 |
TLRKTVEDYF C FCYGKALGKS |
CCCCCCCCCC C CCCCCCHHHH |
1.55% |
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| 2 |
123 |
RKTVEDYFCF C YGKALGKSTV |
CCCCCCCCCC C CCCCCCHHHH |
4.62% |
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| 3 |
215 |
DRSILSPGGS C GPIKVKTEPT |
CCCCCCCCCC C CCCCCCHHHH |
9.45% |
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| 4 |
34 |
TFLMSALESM C KELAKSKAEV |
CCCCCCCCCC C CCCCCCHHHH |
4.28% |
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| 5 |
475 |
KLRKMVDQLF C KKFAEALGST |
CCCCCCCCCC C CCCCCCHHHH |
6.78% |
22178444
20140087
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| 6 |
745 |
QKVENLFNEK C GEALGLKQAV |
CCCCCCCCCC C CCCCCCHHHH |
4.93% |
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| 7 |
80 |
KDFQKDFVKY C VEEEEKAAEM |
CCCCCCCCCC C CCCCCCHHHH |
2.29% |
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| 8 |
903 |
PYRKITINPG C VVVDGMPPGV |
CCCCCCCCCC C CCCCCCHHHH |
1.9% |
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