UniprotKB/SwissProt ID: P70398 (P70398)
Gene Name:
Usp9x
Organism: Mus musculus (Mouse)
Function: Deubiquitinase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins (PubMed:12895410, PubMed:29626158, PubMed:30951545). May therefore play an important regulatory role at the level of protein turnover by preventing degradation of proteins through the removal of conjugated ubiquitin (PubMed:29626158, PubMed:30951545). Specifically hydrolyzes 'Lys-11'-, followed by 'Lys-63'-, 'Lys-48'- and 'Lys-6'-linked polyubiquitins chains (By similarity). Essential component of TGF-beta/BMP signaling cascade (By similarity). Specifically deubiquitinates monoubiquitinated SMAD4, opposing the activity of E3 ubiquitin-protein ligase TRIM33 (By similarity). Deubiquitinates alkylation repair enzyme ALKBH3 (By similarity). OTUD4 recruits USP7 and USP9X to stabilize ALKBH3, thereby promoting the repair of alkylated DNA lesions (By similarity). Deubiquitinates RNA demethylase enzyme ALKBH5, promoting its stability (By similarity). Deubiquitinates mTORC2 complex component RICTOR at 'Lys-294' by removing 'Lys-63'-linked polyubiquitin chains, stabilizing RICTOR and enhancing its binding to MTOR, thus promoting mTORC2 complex assembly (By similarity). Regulates chromosome alignment and segregation in mitosis by regulating the localization of BIRC5/survivin to mitotic centromeres (By similarity). Involved in axonal growth and neuronal cell migration (PubMed:24607389). Regulates cellular clock function by enhancing the protein stability and transcriptional activity of the core circadian protein BMAL1 via its deubiquitinating activity (PubMed:29626158). Acts as a regulator of peroxisome import by mediating deubiquitination of PEX5: specifically deubiquitinates PEX5 monoubiquitinated at 'Cys-11' following its retrotranslocation into the cytosol, resetting PEX5 for a subsequent import cycle (By similarity). Deubiquitinates PEG10 (PubMed:30951545). Inhibits the activation of the Hippo signaling pathway via deubiquitination of AMOTL2 at 'Lys-337' and 'Lys-404' which prohibits its interaction with and activation of LATS2. Loss of LATS2 activation and subsequent loss of YAP1 phosphorylation results in an increase in YAP1-driven transcription of target genes (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm, cytosol. Cell projection, growth cone. Cytoplasm, cytoskeleton, cilium axoneme
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