Protein Name:
Phosphatidylethanolamine-binding protein 1
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UniprotKB/SwissProt ID: P70296 (P70296)
Gene Name:
Pebp1
Organism: Mus musculus (Mouse)
Function: Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase. Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation (By similarity) HCNP may be involved in the function of the presynaptic cholinergic neurons of the central nervous system. HCNP increases the production of choline acetyltransferase but not acetylcholinesterase. Seems to be mediated by a specific receptor (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P70296
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
13 |
ADISQWAGPL C LQEVDEPPQH |
CCCCHHHHCC C CCCCCCCCCC |
4.08% |
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| 2 |
133 |
LVYEQEQPLS C DEPILSNKSG |
CCCCHHHHCC C CCCCCCCCCC |
10.14% |
22178444
19483679
21278135
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| 3 |
168 |
YNLGAPVAGT C YQAEWDDYVP |
CCCCHHHHCC C CCCCCCCCCC |
2.01% |
21278135
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