Protein Name:
Lipid droplet-regulating VLDL assembly factor AUP1
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UniprotKB/SwissProt ID: P70295 (P70295)
Gene Name:
Aup1
Organism: Mus musculus (Mouse)
Function: Plays a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome (By similarity). Plays a role in lipid droplet formation (By similarity). Induces lipid droplet clustering (By similarity). Recruits ubiquitin-conjugating enzyme UBE2G2 to lipid droplets which facilitates its interaction with ubiquitin ligases AMFR/gp78 and RNF139/TRC8, leading to sterol-induced ubiquitination of HMGCR and its subsequent proteasomal degradation (By similarity). Also required for the degradation of INSIG1, SREBF1 and SREBF2 (By similarity). Plays a role in regulating assembly and secretion of very low density lipoprotein particles and stability of apolipoprotein APOB (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Endoplasmic reticulum membrane. Lipid droplet
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Graphical Visualization of S-nitrosylation Sites:
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