Protein Name:
Plexin-A1
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UniprotKB/SwissProt ID: P70206 (P70206)
Gene Name:
Plxna1
Organism: Mus musculus (Mouse)
Function: Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm. Acts as coreceptor of TREM2 for SEMA6D in dendritic cells and is involved in the generation of immune responses and skeletal homeostasis (PubMed:16715077)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P70206
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
1011 |
FSWRNSREIR C LTPPGHTPGS |
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| 2 |
374 |
KEKIKERIQS C YRGEGKLSLP |
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| 3 |
742 |
QPQSGQRGYE C LFHIPGSPAR |
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