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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Hemoglobin subunit beta

UniprotKB/SwissProt ID: P68871 (P68871)

Gene Name: HBB

Organism: Homo sapiens (Human)

Function: Involved in oxygen transport from the lung to the various peripheral tissues LVV-hemorphin-7 potentiates the activity of bradykinin, causing a decrease in blood pressure Functions as an endogenous inhibitor of enkephalin-degrading enzymes such as DPP3, and as a selective antagonist of the P2RX3 receptor which is involved in pain signaling, these properties implicate it as a regulator of pain and inflammation

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization:

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR000971 Globin
IPR009050 Globin-like_sf
IPR012292 Globin/Proto
IPR002337 Hemoglobin_b
IPR050056 Hemoglobin_oxygen_transport

The S-nitrosylation sites of P68871

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 113 NFRLLGNVLV C VLAHHFGKEF  CCCCCHHHHH H HHHHHCCCCH  1.49% 25040305
2 94 GTFATLSELH C DKLHVDPENF  CCCCCHHHHH H HHHHHCCCCH  8.46% 9843411
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