Protein Name:
cAMP-dependent protein kinase catalytic subunit beta
|
UniprotKB/SwissProt ID: P68181 (P68181)
Gene Name:
Prkacb
Organism: Mus musculus (Mouse)
Function: Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs (By similarity). PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux (PubMed:9368018). Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis (By similarity). Phosphorylates GPKOW which regulates its ability to bind RNA (By similarity). Acts as a negative regulator of mTORC1 by mediating phosphorylation of RPTOR (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Cell membrane. Membrane. Nucleus
|
|
|
Graphical Visualization of S-nitrosylation Sites:
|
|
The S-nitrosylation sites of P68181
|
| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
349 |
SITEKCGKEF C EF-------- |
|
|
|
|
