Protein Name:
Casein kinase II subunit beta
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UniprotKB/SwissProt ID: P67870 (P67870)
Gene Name:
CSNK2B
Organism: Homo sapiens (Human)
Function: Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine (PubMed:11239457, PubMed:16818610). Participates in Wnt signaling (By similarity) (Microbial infection) Upon infection with Epstein-Barr virus (EBV), the interaction with viral EBNA1 increases the association of CK2 with PML proteins, which increases PML phosphorylation by CK2, triggering the polyubiquitylation and degradation of PML (PubMed:20719947, PubMed:24216761). Seems to also suppress EBV reactivation by mediating ARK2N and JUN at the Z promoter which inhibits BZLF1 transcrition (PubMed:31341047)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P67870
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
109 |
EKYQQGDFGY C PRVYCENQPM |
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| 2 |
114 |
GDFGYCPRVY C ENQPMLPIGL |
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| 3 |
140 |
EAMVKLYCPK C MDVYTPKSSR |
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| 4 |
23 |
FCGLRGNEFF C EVDEDYIQDK |
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