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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Small ribosomal subunit protein eS12

UniprotKB/SwissProt ID: P63323 (P63323)

Gene Name: Rps12

Organism: Mus musculus (Mouse)

Function: Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (By similarity). Subunit of the 40S ribosomal complex (By similarity)

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus, nucleolus

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR029064 Ribosomal_eL30-like_sf
IPR004038 Ribosomal_eL8/eL30/eS12/Gad45
IPR000530 Ribosomal_eS12
IPR047860 Ribosomal_eS12_CS

The S-nitrosylation sites of P63323

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 106 REGKPRKVVG C SCVVVKDYGK  CCCCCCCCCC C CCHHHHHHHH  1.6%
2 108 GKPRKVVGCS C VVVKDYGKES  CCCCCCCCCC C CCHHHHHHHH  2.91%
3 50 KALDKRQAHL C VLASNCDEPM  CCCCCCCCCC C CCHHHHHHHH  1.37% 20925432
4 56 QAHLCVLASN C DEPMYVKLVE  CCCCCCCCCC C CCHHHHHHHH  6.09% 24926564
5 69 PMYVKLVEAL C AEHQINLIKV  CCCCCCCCCC C CCHHHHHHHH  7.29% 20925432
6 92 NKKLGEWVGL C KIDREGKPRK  CCCCCCCCCC C CCHHHHHHHH  2.74% 21278135