Protein Name:
SUMO-conjugating enzyme UBC9
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UniprotKB/SwissProt ID: P63279 (P63279)
Gene Name:
UBE2I
Organism: Homo sapiens (Human)
Function: Accepts the ubiquitin-like proteins SUMO1, SUMO2, SUMO3, SUMO4 and SUMO1P1/SUMO5 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2, CBX4 and ZNF451. Can catalyze the formation of poly-SUMO chains. Necessary for sumoylation of FOXL2 and KAT5. Essential for nuclear architecture and chromosome segregation. Sumoylates p53/TP53 at 'Lys-386'. Mediates sumoylation of ERCC6 which is essential for its transcription-coupled nucleotide excision repair activity (PubMed:26620705)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus. Cytoplasm. Cytoplasm, perinuclear region
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P63279
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
138 |
PAQAEAYTIY C QNRVEYEKRV |
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| 2 |
43 |
DGTMNLMNWE C AIPGKKGTPW |
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