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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Actin, cytoplasmic 2

UniprotKB/SwissProt ID: P63260 (P63260)

Gene Name: Actg1

Organism: Mus musculus (Mouse)

Function: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Plays a role in the repair of noise-induced stereocilia gaps following recruitment by XIRP2 isoform 3, thereby maintains hearing sensitivity following loud noise damage (PubMed:37294664)

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm, cytoskeleton

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR004000 Actin
IPR020902 Actin/actin-like_CS
IPR004001 Actin_CS
IPR043129 ATPase_NBD

The S-nitrosylation sites of P63260

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 217 EIVRDIKEKL C YVALDFEQEM   
2 257 VITIGNERFR C PEALFQPSFL   
3 272 FQPSFLGMES C GIHETTFNSI   
4 285 HETTFNSIMK C DVDIRKDLYA   
5 374 ESGPSIVHRK C F---------