Protein Name:
Inward rectifier potassium channel 2
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UniprotKB/SwissProt ID: P63252 (P63252)
Gene Name:
KCNJ2
Organism: Homo sapiens (Human)
Function: Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it (PubMed:36149965, PubMed:7590287, PubMed:9490857). Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages (PubMed:7590287, PubMed:7696590). The inward rectification is mainly due to the blockage of outward current by internal magnesium (PubMed:9490857). Can be blocked by extracellular barium or cesium (PubMed:7590287, PubMed:7696590). Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues (PubMed:7590287, PubMed:7696590, PubMed:7840300)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane. Cell membrane, sarcolemma, T-tubule
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P63252
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
76 |
QRYLADIFTT C VDIRWRWMLV |
CCCCCCCCEE E EECCCHHHHH |
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19608980
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