UniprotKB/SwissProt ID: P63170 (P63170)
Gene Name:
Dynll1
Organism: Rattus norvegicus (Rat)
Function: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function (PubMed:11746667, PubMed:8702622). Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules (PubMed:11746667, PubMed:8702622). May play a role in changing or maintaining the spatial distribution of cytoskeletal structures (PubMed:11746667, PubMed:8702622). In addition to its role in cytoskeleton and transport, acts as a protein-protein adapter, which inhibits and/or sequesters target proteins (By similarity). Involved in the response to DNA damage by acting as a key regulator of DNA end resection: when phosphorylated at Ser-88, recruited to DNA double-strand breaks (DSBs) by TP53BP1 and acts by disrupting MRE11 dimerization, thereby inhibiting DNA end resection (By similarity). In a subset of DSBs, DYNLL1 remains unphosphorylated and promotes the recruitment of the Shieldin complex (By similarity). Binds and inhibits the catalytic activity of neuronal nitric oxide synthase/NOS1 (PubMed:8864115). Promotes transactivation functions of ESR1 and plays a role in the nuclear localization of ESR1 (By similarity). Regulates apoptotic activities of BCL2L11 by sequestering it to microtubules (By similarity). Upon apoptotic stimuli the BCL2L11-DYNLL1 complex dissociates from cytoplasmic dynein and translocates to mitochondria and sequesters BCL2 thus neutralizing its antiapoptotic activity (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome. Cytoplasm, cytoskeleton. Nucleus. Mitochondrion
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