Protein Name:
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform
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UniprotKB/SwissProt ID: P63151 (P63151)
Gene Name:
PPP2R2A
Organism: Homo sapiens (Human)
Function: Substrate-recognition subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit (PubMed:1849734, PubMed:33108758). Involved in chromosome clustering during late mitosis by mediating dephosphorylation of MKI67 (By similarity). Essential for serine/threonine-protein phosphatase 2A-mediated dephosphorylation of WEE1, preventing its ubiquitin-mediated proteolysis, increasing WEE1 protein levels, and promoting the G2/M checkpoint (PubMed:33108758)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization:
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P63151
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
334 |
QVHEYLRSKL C SLYENDCIFD |
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| 2 |
398 |
PRTVLKPRKV C ASGKRKKDEI |
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