Protein Name:
Ubiquitin-conjugating enzyme E2 B
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UniprotKB/SwissProt ID: P63147 (P63147)
Gene Name:
Ube2b
Organism: Mus musculus (Mouse)
Function: E2 ubiquitin-conjugating enzyme that accepts ubiquitin from the ubiquitin-activating enzyme E1 and transfers it to a E3 ubiquitin-protein ligase (PubMed:14585983). In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'- and 'Lys-63'-linked polyubiquitination (By similarity). Together with the E3 enzyme BRE1 (RNF20 and/or RNF40), plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys-120' to form H2BK120ub1 (By similarity). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation (By similarity). May play a role in DNA repair (By similarity). Associates to the E3 ligase RAD18 to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on 'Lys-164' (By similarity). In association with the E3 enzyme UBR4, is involved in N-end rule-dependent protein degradation (By similarity). May be involved in neurite outgrowth (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane. Nucleus
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P63147
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
88 |
HPNVYADGSI C LDILQNRWSP |
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